When Constantine II was killed in an uprising in 1344, Constantine III succeeded him. He was the second king of the Lusignan house. He attempted to wipe out all rival claimants to the throne; he gave orders to kill Constantine II's nephews, Bemon and Leo , but before the murder could be carried out they escaped to Cyprus .
Constantine was the first husband of Maria , daughter of Oshin of Corycos and Jeanne of Anjou . He was predeceased by his two sons. Upon his death from natural causes he was succeeded by his cousin Constantine IV